The composition of the vaginal microbiota can influence the transmission of pathogens such as HIV. Women colonised with optimal vaginal bacterial communities, typically dominated by beneficial Lactobacillus spp., have a decreased risk of acquiring and transmitting HIV compared to women colonised with non-optimal microbiota.
A non-optimal vaginal microbiota is characterised by a depletion of beneficial Lactobacillus spp. and high relative abundance of non-beneficial bacterial species, as exemplified by bacterial vaginosis (BV), which is a common form of vaginal dysbiosis in women of reproductive age that occurs in up to 55 per cent of women in sub- Saharan Africa where HIV predominates (McKinnon et al 2019 AIDS Res Hum Retroviruses 25(3)).
Non-optimal vaginal microbiota increase local pro-inflammatory cytokines, recruit activated HIV target cells and disrupt cervicovaginal epithelial barrier integrity that together drive increased risk of HIV acquisition. While studies have described the association between the vaginal microbiota and increased susceptibility to HIV and sexually transmitted infections (STIs), relatively little is known about how the microbiota and its metabolites act on the epithelium to mediate this effect.
Major distinguishing features of women colonised with optimal vaginal microbiota compared to women with BV are a dramatic increase in the levels of lactic acid and depletion of short chain fatty acids, suggesting a role for these metabolites as effector molecules of vaginal bacteria and the mucosal environment.
Projects are available to determine the direct anti-HIV and bactericidal mechanisms of vaginal microbiota metabolites (VMBs) including:
These studies underpin an exciting program at Burnet to advance antibiotic-sparing strategies to optimise the vaginal microbiota and dampen genital inflammation to decrease susceptibility to HIV, and other STIs as well as adverse reproductive health outcomes.
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