Projects

Profiling immune responses in paediatric and high-risk populations to the COVID-19 virus (PROPHECY)

COVID-19 vaccines protect against severe disease. But people with underlying health conditions remain at risk of infection and associated complications. This study will evaluate immune responses after infection or vaccination in healthy and vulnerable people. The findings will inform future clinical care for COVID-19 and targeted approaches to improve vaccine responses in vulnerable patient groups.

We're evaluating antibody and cellular immune responses after infection or vaccination in healthy and vulnerable people to evaluate their protection against future variants.

We'll comprehensively profile the immune responses to the COVID-19 virus (SARS-CoV-2) using clinical samples collected from 11 vulnerable and immunocompromised cohorts (adults and paediatrics) and healthy individuals who have been vaccinated. Serological antibody responses and cellular responses T-cells and B-cell will be measured.

Generating knowledge and evidence to improve vaccine schedules, future booster strategies and improved access to clinical care for vulnerable populations. In addition, our findings will inform future clinical trials to enhance vaccine responses in immunocompromised people.

Timeline

2022–2026.

Publications

08 Aug 2024

Fourth dose bivalent COVID-19 vaccines outperform monovalent boosters in eliciting cross-reactive memory B cells to Omicron subvariants

Journal of Infection

P. Mark Hogarth

01 Jan 2024

Serological responses and clinical outcomes following a three‐dose primary COVID‐19 vaccine schedule in kidney transplant recipients and people on dialysis

Clinical & Translational Immunology

Shir Sun, Irene Boo, Heidi E. Drummer, Gabriela Khoury, Irene Boo, Shir Sun, Heidi E. Drummer, Gabriela Khoury

16 Jun 2023

COVID-19 Adenoviral Vector Vaccination Elicits a Robust Memory B Cell Response with the Capacity to Recognize Omicron BA.2 and BA.5 Variants

Journal of Clinical Immunology

Irene Boo, P. Mark Hogarth, Heidi E. Drummer

Partners

Funding partners

Medical Research Future Fund (MRFF): 2021 COVID-19 Treatment Access and Public Health Activities.

Collaborators

Alfred Health
Monash Health
Monash University
Murdoch Children’s Research Institute

Consumer health partners

Spleen Australia
AusPIPS
National Association of people with HIV Australia
Musculoskeletal (MSK) Australia
Crohn’s and Colitis Australia
Safer Care Victoria

Project contacts

Main contacts

Health themes

Projects

Published research

Careers

Study at Burnet

About us

Where we work

Profiling immune responses in paediatric and high-risk populations to the COVID-19 virus (PROPHECY)

Timeline

Publications

Fourth dose bivalent COVID-19 vaccines outperform monovalent boosters in eliciting cross-reactive memory B cells to Omicron subvariants

Serological responses and clinical outcomes following a three‐dose primary COVID‐19 vaccine schedule in kidney transplant recipients and people on dialysis

COVID-19 Adenoviral Vector Vaccination Elicits a Robust Memory B Cell Response with the Capacity to Recognize Omicron BA.2 and BA.5 Variants

Partners

Funding partners

Collaborators

Consumer health partners

Project contacts

Main contacts

Professor Heidi Drummer

Scientific Director for Research Translation; Scientific Director, Burnet Diagnostics Initiative; Principal Investigator, Burnet Vaccine Initiative; Co-Head, Viral Entry and Vaccines Group

Dr Gabriela Khoury

Theme Leader, Antiviral Immunity

Project team

Professor Heidi Drummer

Scientific Director for Research Translation; Scientific Director, Burnet Diagnostics Initiative; Principal Investigator, Burnet Vaccine Initiative; Co-Head, Viral Entry and Vaccines Group

Dr Gabriela Khoury

Theme Leader, Antiviral Immunity

Irene Boo

Research Assistant, Drummer/Poumbourios Laboratory

Dr Dilini Rathnayake

Research Officer

Dr James McMahon

Adjunct Senior Research Fellow

Alfred Hospital; Monash University

Professor Menno van Zelm

Professor of Molecular Immunology

Monash University; Erasmus University Medical Center, Netherlands

Dr Ian Woolley

Infectious Diseases Physician; Director, Monash Infectious Diseases

Monash Infectious Diseases, Monash University

Associate Professor Alberta Hoi

Senior Consultant

Monash Health

Professor Anne Holland

Professor of Physiotherapy

Alfred Health; Monash University

Professor David Curtis

Clinical Haematologist

Alfred Health; Monash University

Dr Miles Sparrow

Adjunct Clinical Associate Professor

Alfred Health; Monash University

Associate Professor James Trauer

Head of Epidemiological Modelling

School of Public Health and Preventive Medicine, Monash University

Dr Benjamin Rogers

Adjunct Clinical Associate Professor

Monash Health; Monash University

Associate Professor William Mulley

Nephrologist

Monash Health

Dr Samar Ojaimi

Infectious Diseases Physician

Monash Health

Dr Ed Giles

Research Fellow

Monash University

Associate Professor Paul Licciardi

Group Leader of Vaccine Immunology

Murdoch Children’s Research Institute

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