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Optima HIV modelling

The Optima HIV model was launched in 2012 but precursors to the model were in development from 2004. Since the Optima launch in 2012, the model has been applied worldwide.

Findings from Optima HIV applications and studies have been used to inform: the United Nations General Assembly, Global Fund to Fight AIDS, Tuberculosis and Malaria, Association of Southeast Asian Nations, national HIV/AIDS Strategic Plans, national Global Fund Concept Note applications, and country reports.

Optima HIV results can be used to improve country and health policy decision-making by informing domestic and donor public health funding allocations towards better achieving HIV targets.

The Optima HIV software was conceptualised and developed by the Optima Consortium for Decision Science with technical input from the World Bank, and is owned by Optima Consortium for Decision Science, Ltd. Optima HIV can be reached through and is free and open source, with the code available for download on GitHub.

Optima HIV helps to:

  • identify HIV programs to be prioritized with available funding
  • determine resources required to reach HIV coverage targets and epidemiological objectives
  • establish the most cost-effective mix of HIV interventions to respond to a country’s HIV epidemic
  • reveal the investment allocation and coverage allocation for minimizing HIV incidence, HIV-related mortality, or both
  • calculate future treatment, care, and support costs for people living with HIV or AIDS
  • estimate the number of new HIV infections and HIV-related deaths averted through existing or optimized investment. 

Timeline

2004–ongoing.

Diagrams

Diagram showing HIV pathways such as infection, diagnosis, treatment, follow-up, care and disease recovery.

HIV 'care cascade' of testing, treatment and recovery.

Diagram showing how HIV can be transmitted between population groups.

HIV can be transmitted through sex, injecting activities and perinatal exposure.

National Cancer Institute Ci8t6zedbzw Unsplash

Access Optima HIV

Access the Optima HIV open source model.

User guide and training materials

Technical reports

  • Allocation of HIV resources in Azerbaijan

    Optimizing spending would involve deprioritizing HIV testing for the general population to enable continued scale up of treatment, as well as HIV programs for men who have sex with men and people who inject drugs.

    Allocation of HIV resources in Azerbaijan [PDF 1.6 MB]
  • Allocation of HIV resources in Belarus

    Optimizing spending would involve deprioritizing HIV testing among the general population to enable continued scale up of ART for all populations and HIV prevention and testing programs for people who inject drugs.

    Allocation of HIV resources in Belarus [PDF 1.8 MB]
  • Allocation of HIV resources in Georgia

    HIV spending allocations in Georgia are estimated to be close to optimized already, with prioritisation of effective key population programs.

    Allocation of HIV resources in Georgia [PDF 1.6 MB]
  • Allocation of HIV resources in Kazakhstan

    Optimizing spending would involve deprioritising HIV testing among the general population to enable continued scale up of antiretroviral therapy, pre-exposure prophylaxis for men who have sex with men, and needle-syringe programs for people who inject drugs.

    Allocation of HIV resources in Kazakhstan [PDF 1.8 MB]
  • Allocation of HIV resources in Kosovo

    The current HIV spending allocation is estimated to be close to optimised. Further optimisation would explore opportunities to scale up antiretroviral therapy coverage by improving linkage and retention to treatment, and strategic information about people who leave the county for treatment in other settings.

    Allocation of HIV resources in Kosovo [PDF 1.6 MB]
  • Allocation of HIV resources in Kyrgyzstan

    Optimizing spending would involve deprioritizing HIV testing for the general<br/>population to enable continued scale up of antiretroviral therapy and maintain spending for programs for people who inject drugs.

    Allocation of HIV resources in Kyrgyzstan [PDF 1.7 MB]
  • Allocation of HIV resources in Moldova

    Optimizing spending would involve deprioritizing condom promotion and distribution, needle-syringe programs (NSP) and prevention programs for female sex workers, to continue scaling up antiretroviral therapy for all populations and HIV programs for men who have sex with men.

    Allocation of HIV resources in Moldova [PDF 3.0 MB]
  • Allocation of HIV resources in Serbia

    Potential savings from reduced antiretroviral therapy unit costs could be reinvested among HIV programs funded by the Republic Health Insurance Fund; optimally this would include further scale-up of antiretroviral therapy followed by investment in pre-exposure prophylaxis (PrEP).

    Allocation of HIV resources in Serbia [PDF 1.7 MB]
  • Allocation of HIV resources in Tajikistan

    Optimizing spending would involve continued scale up of antiretroviral therapy and a shift in emphasis toward HIV programs for female sex workers and migrants while maintaining substantial investment in programs for people who inject drugs.

    Allocation of HIV resources in Tajikistan [PDF 1.6 MB]
  • Allocation of HIV resources in Uzbekistan

    We estimated the optimized resource allocations within counties, whereby the total HIV budget for each county was kept the same, and across counties, where resources could be shifted between counties.

    Allocation of HIV resources in Uzbekistan [PDF 1.7 MB]
  • Improving allocative efficiency of the HIV response in Kenya

    We estimated the optimized resource allocations within counties, whereby the total HIV budget for each county was kept the same, and across counties, where resources could be shifted between counties.

    Improving allocative efficiency of the HIV response in Kenya [PDF 5.0 MB]
  • Ending the AIDS epidemic in Cambodia

    The main purpose of this analysis is to develop an investment scenario that maximises the impact of resource allocations in HIV prevention, tailored to the needs of key populations, differentiated to subpopulations by risk and age, and aligned with the Global AIDS Strategy.

    Ending the AIDS epidemic in Cambodia [PDF 8.2 MB]
  • Resource optimization to maximize the HIV response in Eastern Europe and Central Asia

    Allocative efficiency modeling analyses were conducted in 11 countries in EECA through partnership with the country Governments, the Global Fund to Fight AIDS, Tuberculosis and Malaria, UNAIDS, and Burnet Institute. Participating countries included Armenia, Azerbaijan, Belarus, Georgia, Kazakhstan, Kyrgyzstan, Moldova, Romania, Tajikistan, Ukraine, and Uzbekistan.

    Resource optimization to maximize the HIV response in Eastern Europe and Central Asia [PDF 804.4 kB]
  • Оптимизация ресурсов для максимизации противодействия эпидемии ВИЧ в Восточной Европе и Центральной Азии

    Результаты анализа с применением модели Optima HIV для 11 стран Восточной Европы и Центральной Азии.

    Оптимизация ресурсов для максимизации противодействия эпидемии ВИЧ в Восточной Европе и Центральной Азии [PDF 852.6 kB]
  • Improving efficiency of the HIV response in Malawi

    This report outlines findings from an HIV modeling analysis conducted for Malawi by the country team, the Global Fund to Fight AIDS, Tuberculosis and Malaria, the Clinton Health Access Initiative (CHAI), and the Optima Consortium for Decision Science.

    Improving efficiency of the HIV response in Malawi [PDF 2.2 MB]
  • Resource optimization to maximize the HIV response in Armenia

    An allocative efficiency modeling analysis was conducted through partnership with the Armenian Government, the Global Fund, UNAIDS and Burnet Institute. The Optima HIV model was applied to estimate the optimized resource allocation across a mix of HIV programs.

    Resource optimization to maximize the HIV response in Armenia [PDF 931.4 kB]
  • Resource optimization to maximize the HIV response in Azerbaijan

    An allocative efficiency modeling analysis was conducted through partnership with the Azerbaijani Government, the Global Fund, UNAIDS and Burnet Institute. The Optima HIV model was applied to estimate the optimized resource allocation across a mix of HIV programs.

    Resource optimization to maximize the HIV response in Azerbaijan [PDF 1.2 MB]
  • Resource optimization to maximize the HIV response in Belarus

    An allocative efficiency modeling analysis was conducted through partnership with the Belarusian Government, the Global Fund, UNAIDS and Burnet Institute. The Optima HIV model was applied to estimate the optimized resource allocation across a mix of HIV programs.

    Resource optimization to maximize the HIV response in Belarus [PDF 920.3 kB]
  • Resource optimization to maximize the HIV response in Georgia

    An allocative efficiency modeling analysis was conducted through partnership with the Georgian Government, the Global Fund, UNAIDS and Burnet Institute. The Optima HIV model was applied to estimate the optimized resource allocation across a mix of HIV programs.

    Resource optimization to maximize the HIV response in Georgia [PDF 860.5 kB]
  • Resource optimization to maximize the HIV response in Kazakhstan

    An allocative efficiency modeling analysis was conducted through partnership with the Kazak Government, the Global Fund, UNAIDS and Burnet Institute. The Optima HIV model was applied to estimate the optimized resource allocation across a mix of HIV programs.

    Resource optimization to maximize the HIV response in Kazakhstan [PDF 937.4 kB]
  • Resource optimization to maximize the HIV response in Kyrgyzstan

    An allocative efficiency modeling analysis was conducted through partnership with the Kyrgyz Government, the Global Fund, UNAIDS and Burnet Institute. The Optima HIV model was applied to estimate the optimized resource allocation across a mix of HIV programs.

    Resource optimization to maximize the HIV response in Kyrgyzstan [PDF 1.5 MB]
  • Resource optimization to maximize the HIV response in Moldova

    An allocative efficiency modeling analysis was conducted through partnership with the Moldovan Government, the Global Fund, UNAIDS, and Burnet Institute. The Optima HIV model was applied to estimate the optimized resource allocation across a mix of HIV programs.

    Resource optimization to maximize the HIV response in Moldova [PDF 1.4 MB]
  • Resource optimization to maximize the HIV response in Romania

    An allocative efficiency modeling analysis was conducted through partnership with the Government of Romania, the Global Fund, UNAIDS and Burnet Institute. The Optima HIV model was applied to estimate the optimized resource allocation across a mix of HIV programs.

    Resource optimization to maximize the HIV response in Romania [PDF 1.0 MB]
  • Resource optimization to maximize the HIV response in Tajikistan

    An allocative efficiency modeling analysis was conducted through partnership with the Tajikistani Government, the Global Fund, UNAIDS, and Burnet Institute. The Optima HIV model was applied to estimate the optimized resource allocation across a mix of HIV programs.

    Resource optimization to maximize the HIV response in Tajikistan [PDF 890.3 kB]
  • Resource optimization to maximize the HIV response in Ukraine

    An allocative efficiency modeling analysis was conducted through partnership with the Ukrainian Government, the Global Fund, UNAIDS and Burnet Institute. The Optima HIV model was applied to estimate the optimized resource allocation across a mix of HIV programs.

    Resource optimization to maximize the HIV response in Ukraine [PDF 1.3 MB]
  • Improving the allocative efficiency of the HIV response across the care cascade in Zimbabwe

    Efficiency is needed in the response to further the progress towards national HIV targets. To address this need, a 2-phased HIV epidemic and allocative and implementation efficiency analysis of the HIV response, with a particular focus on the HIV testing and treatment cascade was conducted using Optima HIV. Optima HIV is a mathematical model for determining an optimized resource allocation across a combination of HIV programs for maximizing defined outcomes such as reductions in incidence and deaths.

    Improving the allocative efficiency of the HIV response across the care cascade in Zimbabwe [PDF 5.2 MB]
  • Improving the allocative efficiency of Kosovo’s HIV response

    An allocative efficiency analysis of Kosovo’s HIV response was conducted using Optima HIV, an epidemiological model of HIV transmission that is coupled with a programmatic component and a resource optimization algorithm.

    Improving the allocative efficiency of Kosovo’s HIV response [PDF 1.4 MB]
  • Optimizing investments in the national HIV response of Mexico

    In the hopes of assisting the Government of Mexico in further strengthening its HIV investment, the authors try to answer the question How can HIV funding be optimally allocated to the combination of HIV response interventions that will yield the highest impact in the shortest period.

    Optimizing investments in the national HIV response of Mexico
  • Optimizando la inversión del plan de respuesta de Colombia al VIH

    El objetivo del estudio es mejorar la eficiencia distributiva del gasto nacional en el control del VIH, en apoyo a las políticas nacionales sobre el tema, utilizando una herramienta matemática elaborada conjuntamente por el Banco Mundial y el “Optima Consortium for Decision Science”, denominada ÓPTIMA-VIH.

    Optimizando la inversión del plan de respuesta de Colombia al VIH [PDF 2.1 MB]
  • Allocating HIV funding efficiently in Myanmar

    The report summarizes the findings of an allocative efficiency analysis of Myanmar's national HIV epidemic and response.

    Allocating HIV funding efficiently in Myanmar
  • Allocative efficiency analysis (HIV) 2015–2030 for Karnataka and Punjab, India

    The objective of the analysis was to determine (i) the optimal programmatic funding allocations to minimise new HIV infections and deaths and (ii) the optimal programmatic funding allocations to achieve specific impact and coverage targets at the lowest costs in the medium-term.

    Allocative efficiency analysis HIV 2015–2030 for Karnataka and Punjab
  • Optimización de las inversiones para la respuesta al VIH en Perú

    Óptimao VIH es un modelo matemático sobre la transmisión y progresión del VIH, integrado en un marco de análisis económico y programas orientados a VIH.

    Optimización de las inversiones para la respuesta al VIH en Perú
  • Optimizing investments for a sustainable and efficient HIV response in Togo

    This report summarizes the findings of an allocative efficiency analysis of Togo’s HIV response.

    Optimizing investments for HIV response in Togo
  • Optimización de la inversión en VIH/SIDA en Argentina

    El objetivo del estudio es realizar el análisis de eficiencia distributiva de VIH mediante una herramienta técnica denominada Óptima VIH.

    Optimización de la inversión en VIH/SIDA en Argentina
  • Ending AIDS in Johannesburg: an analysis of the status and scale-up towards HIV treatment and prevention targets

    This brief provides the key results of a modeling analysis estimating what it would take in terms of programmatic targets and costs for Johannesburg to meet the fast-track targets and demonstrate the impact that this would have.

    Ending AIDS in Johannesburg
  • Optimizing investments for a sustainable and efficient HIV response in Senegal

    The report summarizes the findings of an allocative efficiency analysis to support Senegal's national HIV response.

    Optimizing investments for a sustainable and efficient HIV response in Senegal
  • HIV investment in Cote d’Ivoire: optimized allocation of HIV resources for a sustainable and efficient HIV response

    This report summarizes the findings of an allocative efficiency analysis to support Côte d'Ivoire’s national HIV response.

    HIV investment in Cote d’Ivoire
  • Optimizing investments in Bulgaria’s HIV response

    Bulgaria's HIV response requires a shared, long-term vision for sustainable HIV financing that harnesses wider health sector reforms and emerging financing models.

    Optimizing investments in Bulgaria’s HIV response
  • Optimizing investments in Belarus for the national HIV response

    This report summarizes the findings of an allocative efficiency analysis on Belarus's national HIV epidemic and response conducted in 2014-15.

    Optimizing investments in Belarus for the national HIV response
  • Optimizing investments in the Kyrgyz Republic’s HIV response

    This report summarizes the findings of an allocative efficiency analysis on the Kyrgyz Republic's national HIV epidemic and response conducted in 2014-15.

    Optimizing investments in the Kyrgyz Republic’s HIV response
  • Value for money in Ukraine’s HIV response: strategic investment and improved efficiency

    An HIV allocative efficiency analysis has been carried out, which revealed that there are several key opportunities to change the course of Ukraine’s HIV epidemic.

    Value for money in Ukraine’s HIV response
  • Optimizing investments in Georgia’s HIV response

    Testing key populations and their sexual partners is the most cost-effective strategy to identify those who require antiretroviral therapy.

    Optimizing investments in Georgia’s HIV response
  • Optimizing HIV investments in Armenia

    This report summarizes the findings of an allocative efficiency analysis on Armenia's national HIV epidemic and response conducted in 2014–15.

    Optimizing HIV investments in Armenia
  • Optimizing investments in Kazakhstan’s HIV response

    As part of a regional initiative, Kazakhstan conducted an HIV allocative efficiency analysis in 2014 to 2015 to inform more strategic investment in HIV programs.

    Optimizing investments in Kazakhstan’s HIV response
  • Science addressing drugs and HIV: second scientific statement

    In March 2014, the United Nations Office on Drugs and Crime organized within the frame of the high-level review of the 57th session of CND, the first scientific consultation in Vienna, entitled 'Science addressing drugs and HIV: state of the art', where it brought together leading scientists to discuss the latest developments in prevention and treatment of HIV and AIDS as it relates to drug use.

    Science addressing drugs and HIV: UN second scientific statement [PDF 215.6 kB]
  • Allocative and implementation efficiency in HIV prevention and treatment for people who inject drugs

    Increasing efficiency of HIV programs for people who inject drugs is a key step towards avoiding implicit rationing and transparent allocation of resources where and how they would have the largest impact on the health of people who inject drugs, and thereby ensuring that funding becomes a global best buy in public health.

    Efficiency In HIV Harm Reduction [PDF 384.4 kB]
  • Optimizing investments in the national HIV responses of Indonesia and Thailand

    A report for World Health Organization Southeast Asia Regional Office. Mathematical modelling was conducted to inform development of the new SEAR Health Sector Strategy on HIV.

    Optimizing investments in the national HIV responses of Indonesia and Thailand [PDF 1.0 MB]
  • How allocative efficiency analysis supported by mathematical modelling changed HIV investment in Sudan

    This brief presents a real-life example of how a group of government decision-makers, program managers, researchers and development partners worked together to improve the allocation of HIV resources in Sudan and thereby better address the HIV objectives that the country strives to achieve.

    HIV investment in Sudan
  • Optimizing investments in Moldova’s HIV response

    This report summarizes the findings of an allocative efficiency analysis on Moldova's national HIV epidemic and response conducted in 2014-15.

    Optimizing investments in Moldova’s HIV response
  • Optimizing investments in Former Yugoslav Republic of Macedonia’s HIV response

    This report summarizes the findings of an Allocative efficiency analysis on the Former Yugoslav Republic (FYR) of Macedonia's national HIV epidemic and response conducted in 2014-15.

    Optimizing investments in Former Yugoslav Republic of Macedonia’s HIV response
  • Modelling an optimised HIV investment approach for Uzbekistan

    With a moderate increase of the investment volume until 2020 combined with an optimised investment allocation the national HIV response in Uzbekistan can be brought on a trajectory which fulfils the basic rights to access to all essential HIV services for those in need.

    Uzbekistan HIV 2020 report [PDF 3.3 MB]
  • Zambia’s HIV response

    This report summarizes findings from an allocative efficiency and financial commitment analysis conducted for the Government of Zambia by the World Bank and the University of New South Wales.

    Zambia's HIV response
  • Investing for results: how Asia-Pacific countries can invest for ending AIDS

    This report examines the resource challenges that confront the AIDS response in Asia and the Pacific. It proposes a set of interventions that will help overcome them and steer the region towards ending its AIDS epidemic.

    Investing for results: how Asia-Pacific countries can invest for ending AIDS 2015 [PDF 1.0 MB]
  • Sudan’s HIV response: value for money in a low-level HIV epidemic

    This report summarizes the findings of an allocative efficiency analysis on Sudan s national HIV epidemic and response conducted in 2014.

    Sudan’s HIV response
  • Optimizing allocation of resources for HIV/AIDS responses

    Presented to the United Nations General Assembly. If the world is to end the AIDS epidemic by 2030, rapid progress must be made by 2020. Quickening the pace for essential HIV prevention and treatment approaches will limit the epidemic to more manageable levels and enable countries to move towards the elimination phase.

    UN.General Assembly: optimizing allocation of resources for HIV/AIDS responses [PDF 4.3 MB]
  • HIV mathematical modelling to support Swaziland's development of its HIV investment case

    To assess the HIV investment case in Swaziland we used a mathematical model of HIV transmission and disease progression called Optima (formerly known as Prevtool).

    Swaziland HIV report [PDF 1.8 MB]
  • HIV resource needs, availabilities and gaps across ASEAN countries

    Presentation slides on the AIDS funding landscape in Asia and the Pacific.

    HIV resource needs, availabilities and gaps across ASEAN countries [PDF 1.4 MB]
  • Niger’s HIV response: targeted investments for a health future

    The main objective of the study is to provide a comprehensive analysis of HIV and health financing needs, investment opportunities, and health system development in the context of the Government of Niger's HIV National Strategic Plan 2013-17.

    Niger’s HIV response
  • Ukraine HIV program efficiency study: can Ukraine improve value for money in HIV service delivery?

    With the current changes in the international HIV financing landscape and the anticipated reduction in Global Fund financing, it is expected that the last two years of the Ukraine 2014-­‐18 National AIDS Strategy will require increasing domestic resources, or more efficient implementation of the same services. This leaves Ukraine with approximately three years to develop and implement a transition strategy in order to meet its growing HIV response financing challenge.

    Ukraine HIV Program Efficiency Report [PDF 6.4 MB]
  • HIV investment in Armenia: analysis and recommendations

    Armenia’s response to its HIV epidemic is underfunded, and currently prevalence and incidence are still increasing. Most of Armenia’s HIV funding has historically come from international sources.

    HIV investment in Armenia: analysis and recommendations 2014 [PDF 1.8 MB]
  • Modelling an optimized investment approach for Tajikistan

    With a moderate increase of the investment volume until 2020 combined with an optimized investment allocation the national HIV response in Tajikistan can be brought on a trajectory which fulfils the basic rights to access to essential HIV services for those in need and makes ending the epidemic threat of HIV/AIDS in Tajikistan a realistic goal if an environment without stigma and discrimination is provided so that services available will be accepted and used by the affected communities.

    Modelling an optimized investment approach for Tajikistan [PDF 3.6 MB]
  • Моделирование подхода оптимизированного инвестирования для Таджикистана

    В стремлении продемонстрировать свою наибольшую политическую приверженность борьбе с ВИЧ и СПИД на самом высоком уровне и воспрепятствовать вредному социально-экономическому воздействию, которому подвергаются сообщества, Национальная программа по борьбе с ВИЧ/СПИД в Таджикистане обратилась к донорскому сообществу с просьбой об оказании технического содействия в моделировании для Таджикистана оптимального инвестиционного подхода в контексте устойчивого финансирования национального реагирования на ВИЧ.

    Моделирование подхода оптимизированного инвестирования для Таджикистана [PDF 4.1 MB]
  • Evaluation of a decade of DFID and World Bank-supported HIV and AIDS programmes in Vietnam from 2003 to 2012

    Evaluation of a decade of DFID and World Bank supported HIV and AIDS programmes in Vietnam from 2003 to 2012, including DFID's management response.

    Evaluation of a decade of DFID and World Bank supported HIV and AIDS programmes in Vietnam from 2003 to 2012
  • HIV resource needs, efficient allocation and resource mobilization for the Republic of Belarus

    Acting strategically now can avert 5,800 HIV infections over 5 years; delaying by 3 years would lead to an unnecessary additional 3,000 infections.

    Belarus HIV report 2013 [PDF 8.1 MB]
  • Assessment of the allocation of HIV funding in Indonesia

    This study aimed to estimate the cost-effectiveness and return on investment of HIV programs implemented during 2003-2010 in Indonesia and to contribute to the allocative efficiency of the HIV prevention response in Indonesia.

    Assessment of the allocation of HIV funding in Indonesia
  • Papua New Guinea HIV model: explaining the past, describing the present, and forecasting the future of the HIV epidemic in PNG

    The PNG HIV Model is a detailed mathematical model of HIV transmission in Papua New Guinea. It was developed as a tool to evaluate and understand HIV epidemic trajectories within Papua New Guinea with the purpose of evaluating the impact of potential HIV interventions and to assist with policy development.

    PNG HIV Model Reports [PDF 3.9 MB] PNG HIV Modeling Report Technical Appendix [PDF 1.7 MB] PNG HIV Model Software Manual [PDF 1.1 MB]
  • Evaluation of the epidemiological impact of harm reduction programs on HIV in Vietnam

    This study assessed the effectiveness of efforts to distribute needle-syringes and condoms and changing risk behavior to reduce sharing of injecting equipment and engaging in unprotected sex so that HIV transmission rates would decline.

    Vietnam WB 2011 [PDF 7.2 MB]
  • HIV in Indonesia model

    The HIV in Indonesia model is flexible for users to define and assess different targeted scenario combinations of past and future epidemic patterns and programs. The model is easily adaptable for application to different geographical levels within Indonesia.

    HIV in Indonesia model report [PDF 1.2 MB] HIV in Indonesia model software manual [PDF 416.0 kB]
  • Epidemiology and modeling report on HIV/AIDS in the Philippines

    This report will attempt to evaluate the current epidemiology and the 'low and slow' development of the HIV epidemic in the Philippines.

    Epidemiology and modeling report on HIV/AIDS in the Philippines [PDF 533.6 kB]
  • Evaluation of the potential impact of the global economic crisis on HIV epidemics in Southeast Asia

    Prepared for AusAID, this report presents findings from a study that investigates the potential impact of the economic crisis on HIV epidemics through the use of mathematical modelling.

    Impact of global economic crisis on HIV epidemics in Southeast Asia [PDF 771.8 kB]
  • Mathematical models to investigate recent trends in HIV notifications among men who have sex with men in Australia

    This report suggests promoting condom use and targeting other sexually transmitted infections are the most effective interventions for interrupting HIV in men who have sex with men.

    Modelling HIV among men who have sex with men in Australia [PDF 8.3 MB]

Recent publications

01 Jan 2024

Evaluation of the use of modelling in resource allocation decisions for HIV and TB

BMJ Global Health

Anna L. Bowring, Debra ten Brink, Rowan Martin‐Hughes, Nick Scott

01 Jan 2024

Comparison of Empirically Derived and Model-Based Estimates of Key Population HIV Incidence and the Distribution of New Infections by Population Group in Sub-Saharan Africa

JAIDS Journal of Acquired Immune Deficiency Syndromes

Rowan Martin‐Hughes

01 Jan 2024

Measuring HIV Acquisitions Among Partners of Key Populations: Estimates From HIV Transmission Dynamic Models

JAIDS Journal of Acquired Immune Deficiency Syndromes

Sherrie L. Kelly, Rowan Martin‐Hughes

01 Jan 2024

New HIV Infections Among Key Populations and Their Partners in 2010 and 2022, by World Region: A Multisources Estimation

JAIDS Journal of Acquired Immune Deficiency Syndromes

Debra ten Brink, Rowan Martin‐Hughes, Rowan Martin‐Hughes, Debra ten Brink

27 Oct 2023

A quantitative assessment of the consistency of projections from five mathematical models of the HIV epidemic in South Africa: a model comparison study

BMC Public Health

Debra ten Brink, Rowan Martin‐Hughes, Nisaa Wulan

09 Aug 2022

Transmission reduction, health benefits, and upper-bound costs of interventions to improve retention on antiretroviral therapy: a combined analysis of three mathematical models

The Lancet Global Health

Debra ten Brink, Rowan Martin‐Hughes, Sherrie L. Kelly

26 May 2022

Cost-effectiveness and impact of pre-exposure prophylaxis to prevent HIV among men who have sex with men in Asia: A modelling study

PLoS ONE

Aaron J. Osborne, Debra ten Brink, Rowan Martin‐Hughes, Mark Minnery, David P. Wilson, Sherrie L. Kelly, Debra ten Brink, Rowan Martin‐Hughes, Mark Minnery, Aaron J. Osborne

27 Apr 2022

Cost-effectiveness of easy-access, risk-informed oral pre-exposure prophylaxis in HIV epidemics in sub-Saharan Africa: a modelling study

The Lancet HIV

Rowan Martin‐Hughes, Debra ten Brink, Sherrie L. Kelly

23 Dec 2021

The risks and benefits of providing HIV services during the COVID-19 pandemic

PLoS ONE

Sherrie L. Kelly, Rowan Martin‐Hughes

02 Mar 2021

The Risks and Benefits of Providing HIV Services during the COVID-19 Pandemic

medRxiv (Cold Spring Harbor Laboratory)

Sherrie L. Kelly, Rowan Martin‐Hughes

13 Mar 2020

Sharing the costs of structural interventions: What can models tell us?

International Journal of Drug Policy

Robyn M. Stuart, David P. Wilson

06 Aug 2020

Potential effects of disruption to HIV programmes in sub-Saharan Africa caused by COVID-19: results from multiple mathematical models

The Lancet HIV

Rowan Martin‐Hughes, Debra ten Brink, Sherrie L. Kelly, Debra ten Brink, Rowan Martin‐Hughes, Sherrie L. Kelly, Debra ten Brink, Rowan Martin‐Hughes, Sherrie L. Kelly

29 Oct 2020

Costs of providing HIV care and optimal allocation of HIV resources in Guyana

PLoS ONE

Robyn M. Stuart

12 Nov 2019

Potential health gains in West and Central Africa through savings from lower cost HIV treatment

AIDS

Robyn M. Stuart, Sherrie L. Kelly, Rowan Martin‐Hughes, David P. Wilson

23 Jul 2020

Opportunities for improved HIV prevention and treatment through budget optimization in Eswatini

PLoS ONE

Mark Minnery, David Wilson, Sherrie L. Kelly

19 Jan 2019

Applying the ‘no-one worse off’ criterion to design Pareto efficient HIV responses in Sudan and Togo

AIDS

Robyn M. Stuart, Cliff C. Kerr, David Jacob Kedziora, Rowan Martin‐Hughes, Sherrie L. Kelly, David P. Wilson

10 Jun 2019

What is the impact of a 20% funding cut in international HIV aid from the United States?

AIDS

Debra ten Brink, Rowan Martin‐Hughes, Sherrie L. Kelly, David P. Wilson

01 Jun 2019

Simulating the entire natural course of HIV infection by extending the basic viral dynamics equations to include declining viral clearance

Pathogens and Disease

Janka Petravic, David P. Wilson

12 Nov 2019

Optimal allocation of HIV resources among geographical regions

BMC Public Health

David Jacob Kedziora, Robyn M. Stuart, David P. Wilson

05 Sep 2019

The influence of constraints on the efficient allocation of resources for HIV prevention

AIDS

Robyn M. Stuart, Sherrie L. Kelly, Cliff C. Kerr, Rowan Martin‐Hughes, David P. Wilson

01 Jan 2018

The City of Johannesburg can end AIDS by 2030: modelling the impact of achieving the Fast‐Track targets and what it will take to get there

Journal of the International AIDS Society

Robyn M. Stuart, Cliff C. Kerr, David P. Wilson

16 Mar 2018

Optimization by Adaptive Stochastic Descent

PLoS ONE

Cliff C. Kerr, David P. Wilson

11 Mar 2018

The global Optima HIV allocative efficiency model: targeting resources in efforts to end AIDS

The Lancet HIV

Janka Petravic, Sherrie L. Kelly, Rowan Martin‐Hughes, Robyn M. Stuart, Xiao F Yap, David Jacob Kedziora, Sheharyar Hussain, Iyanoosh Reporter, Cliff C. Kerr, David P. Wilson

01 Apr 2018

How should HIV resources be allocated? Lessons learnt from applying Optima HIV in 23 countries

Journal of the International AIDS Society

Iyanoosh Reporter, Robyn M. Stuart, Sherrie L. Kelly, David Jacob Kedziora, Janka Petravic, Sheharyar Hussain, Xiao F Yap, Rowan Martin‐Hughes, Cliff C. Kerr, David P. Wilson

01 Jul 2018

Cost and cost‐effectiveness analysis of pre‐exposure prophylaxis among men who have sex with men in two hospitals in Thailand

Journal of the International AIDS Society

Robyn M. Stuart, David P. Wilson

01 Oct 2018

Optima attempts to objectively and pragmatically assist countries meet their targets most efficiently and effectively

Journal of the International AIDS Society

David P. Wilson

27 Oct 2017

Achieving 90-90-90 Human Immunodeficiency Virus (HIV) Targets Will Not Be Enough to Achieve the HIV Incidence Reduction Target in Australia

Clinical Infectious Diseases

Nick Scott, Mark Stoové, Sherrie L. Kelly, David P. Wilson, Margaret Hellard

01 Mar 2018

A tale of two countries: progress towards UNAIDS 90‐90‐90 targets in Botswana and Australia

Journal of the International AIDS Society

Tafireyi Marukutira, Mark Stoové, Sherrie L. Kelly, David P. Wilson, Stanley Lüchters, Suzanne M. Crowe

01 Jan 2017

Acute HIV infection detection and immediate treatment estimated to reduce transmission by 89% among men who have sex with men in Bangkok

Journal of the International AIDS Society

David P. Wilson

03 Oct 2017

Getting it right when budgets are tight: Using optimal expansion pathways to prioritize responses to concentrated and mixed HIV epidemics

PLoS ONE

Robyn M. Stuart, Cliff C. Kerr, Iyanoosh Reporter, Rowan Martin‐Hughes, Sheharyar Hussain, Sherrie L. Kelly, David Jacob Kedziora, David P. Wilson

01 Jan 2016

In the interests of time: improving HIV allocative efficiency modelling via optimal time‐varying allocations

Journal of the International AIDS Society

Cliff C. Kerr, Robyn M. Stuart, David P. Wilson

12 May 2016

Local responses to local epidemics for national impact need advanced spatially explicit tools

AIDS

Kelsey L. Grantham, Cliff C. Kerr, David P. Wilson

01 Jan 2016

A no‐brainer for ending AIDS: the case for a harm reduction decade

Journal of the International AIDS Society

David P. Wilson

21 Nov 2016

GBD 2015 and HIV estimates from the Optima model

The Lancet HIV

Sherrie L. Kelly, David P. Wilson

22 Nov 2016

Allocative and implementation efficiency in HIV prevention and treatment for people who inject drugs

International Journal of Drug Policy

Sherrie L. Kelly, David P. Wilson

16 Feb 2017

Kazakhstan can achieve ambitious HIV targets despite expected donor withdrawal by combining improved ART procurement mechanisms with allocative and implementation efficiencies

PLoS ONE

Sherrie L. Kelly, David P. Wilson

01 Jan 2015

The funding landscape for HIV in Asia and the Pacific

Journal of the International AIDS Society

Robyn M. Stuart, David P. Wilson

22 Jun 2005

Allocating Antiretrovirals in South Africa: Using Modeling to Determine Treatment Equity

PLoS Medicine

11 Feb 2005

Designing Equitable Antiretroviral Allocation Strategies in Resource-Constrained Countries

PLoS Medicine

22 Apr 2022

Perspectives on the use of modelling and economic analysis to guide HIV programmes in sub-Saharan Africa

The Lancet HIV

20 Dec 2022

Cost-effectiveness of voluntary medical male circumcision for HIV prevention across sub-Saharan Africa: results from five independent models

The Lancet Global Health

10 Feb 2016

Projecting the epidemiological effect, cost-effectiveness and transmission of HIV drug resistance in Vietnam associated with viral load monitoring strategies

Journal of Antimicrobial Chemotherapy

01 Dec 2014

The cost-effectiveness of harm reduction

International Journal of Drug Policy

24 Mar 2015

Optima

JAIDS Journal of Acquired Immune Deficiency Syndromes

05 Apr 2015

Scaling up of HIV treatment for men who have sex with men in Bangkok: a modelling and costing study

The Lancet HIV

27 Feb 2015

Reorienting the HIV Response in Niger Toward Sex Work Interventions

JAIDS Journal of Acquired Immune Deficiency Syndromes

15 Sep 2015

Can we know in advance whether models will get it right?

The Lancet Global Health

01 Dec 2015

Sustainable HIV treatment in Africa through viral-load-informed differentiated care

Nature

01 Jan 2014

Predicting the population impact of increased HIV testing and treatment in Australia

Sexual Health

01 Jan 2014

Spending of HIV resources in Asia and Eastern Europe: systematic review reveals the need to shift funding allocations towards priority populations

Journal of the International AIDS Society

01 Jul 2014

Cost-Effectiveness of Antiretroviral Therapy Expansion Strategies in Vietnam

AIDS Patient Care and STDs

10 Dec 2013

Health benefits, costs, and cost-effectiveness of earlier eligibility for adult antiretroviral therapy and expanded treatment coverage: a combined analysis of 12 mathematical models

The Lancet Global Health

01 Sep 2013

HIV antiretroviral prophylaxis for injecting drug users

The Lancet

29 Nov 2013

HIV service capacity: identifying current and future areas of clinical shortage

Sexual Health

02 Jan 2014

A Cost-effectiveness Analysis of HIV Preexposure Prophylaxis for Men Who Have Sex With Men in Australia

Clinical Infectious Diseases

10 Jul 2012

HIV Treatment as Prevention: Natural Experiments Highlight Limits of Antiretroviral Treatment as HIV Prevention

PLoS Medicine

10 Jul 2012

HIV Treatment as Prevention: Principles of Good HIV Epidemiology Modelling for Public Health Decision-Making in All Modes of Prevention and Evaluation

PLoS Medicine

09 Aug 2012

Projected Demographic Profile of People Living with HIV in Australia: Planning for an Older Generation

PLoS ONE

29 Aug 2012

Estimating the cost-effectiveness of needle-syringe programs in Australia

AIDS

10 Jul 2012

HIV Treatment as Prevention: Models, Data, and Questions—Towards Evidence-Based Decision-Making

PLoS Medicine

19 Nov 2012

Demand for HIV clinical services is increasing in Australia but supply is decreasing

Sexual Health

15 Feb 2013

The Potential Cost and Benefits of Raltegravir in Simplified Second-Line Therapy among HIV Infected Patients in Nigeria and South Africa

PLoS ONE

19 Apr 2011

Economic evaluation of monitoring virologic responses to antiretroviral therapy in HIV-infected children in resource-limited settings

AIDS

27 Jun 2011

Expected epidemiological impact of the introduction of a partially effective HIV vaccine among men who have sex with men in Australia

Vaccine

05 Jul 2011

Expected epidemiological impacts of introducing an HIV vaccine in Thailand: A model-based analysis

Vaccine

01 Jan 2010

An HIV epidemic is ready to emerge in the Philippines

Journal of the International AIDS Society

09 Sep 2010

How low can you go: the impact of a modestly effective HIV vaccine compared with male circumcision

AIDS

06 Jul 2009

The Impact of Needle and Syringe Programs on HIV and HCV Transmissions in Injecting Drug Users in Australia: A Model-Based Analysis

JAIDS Journal of Acquired Immune Deficiency Syndromes

12 Nov 2009

Cost‐Effectiveness of Adult Circumcision in a Resource‐Rich Setting for HIV Prevention among Men Who Have Sex with Men

The Journal of Infectious Diseases

01 Nov 2009

What Impact Might the Economic Crisis have on HIV Epidemics in Southeast Asia?

Current HIV Research

01 Jan 2008

Using mathematical modelling to help explain the differential increase in HIV incidence in New South Wales, Victoria and Queensland: importance of other sexually transmissible infections

Sexual Health

06 Aug 2008

Mathematical models and health economic aspects of microbicides

Current Opinion in HIV and AIDS

08 Jul 2008

The paradoxical effects of using antiretroviral-based microbicides to control HIV epidemics

Proceedings of the National Academy of Sciences

01 Jul 2008

Relation between HIV viral load and infectiousness: a model-based analysis

The Lancet

19 Jun 2007

How far will we need to go to reach HIV-infected people in rural South Africa?

BMC Medicine

13 Sep 2006

Predicting the epidemiological impact of antiretroviral allocation strategies in KwaZulu-Natal: The effect of the urban–rural divide

Proceedings of the National Academy of Sciences

24 Mar 2006

Rational Choices for Allocating Antiretrovirals in Africa: Treatment Equity, Epidemiological Efficiency, and Feasibility

PLoS Medicine

Partners

Funding partners

  • World Bank
  • Global Fund to Fight AIDS, Tuberculosis and Malaria
  • World Health Organization
  • United States Centers for Disease Control
  • Australian National Health and Medical Research Council

Collaborators

HIV Modelling Consortium

Project contacts

Main contact

Associate Professor Nick Scott

Associate Professor Nick Scott

Head, Modelling and Biostatistics
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Project team

Dr Rowan  Martin-Hughes

Dr Rowan Martin-Hughes

Senior Research Officer
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Associate Professor Nick Scott

Associate Professor Nick Scott

Head, Modelling and Biostatistics
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Kelvin Burke

Kelvin Burke

Mathematical Modeller
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Anna Roberts

Anna Roberts

Senior Project Manager
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Dr Debra ten Brink

Dr Debra ten Brink

Senior Research Officer
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Nisa Wulan

Nisa Wulan

Health Modeller
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