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HOMER2 study

Hepatocellular carcinoma (HCC) incidence is increasing in Australia and is associated with high mortality. However, there is limited data on the epidemiology of liver cancer in Australia, including the impact.

Objective

The project aims to:

  1. describe trends in HCC incidence and aetiology over time in Victoria
  2. describe trends in mortality rates for HCC over time
  3. determine factors associated with survival, including health services utilization and enrolment in liver cancer surveillance
  4. describe the impact of marginalization on HCC stage at diagnosis, treatment uptake and clinical outcomes

Timeline

2012–2025.

Approach

Prospective cohort study with data linkage.

Community impact

Understanding the rapidly changing trends in the epidemiology of HCC in Victoria is essential to design effective prevention programs.

Treatment approaches to HCC are changing rapidly.

This study will provide evidence for factors that are associated with improved survival outcomes to inform cost-effectiveness modelling.

Partners

Funding partners

  • NHMRC Program grant
  • Ramsay Program grant
  • Gilead Sciences
  • Eisai Australia

Collaborators

  • Melbourne Liver Group
  • St Vincent’s Hospital Melbourne
  • Western Health
  • Northern Health
  • Eastern Health
  • Melbourne Health
  • Alfred Health
  • Austin Health
  • Monash Health

Project contacts

Associate Professor Jessica Howell

Associate Professor Jessica Howell

Co-head, Hepatitis B and Liver Cancer; Senior Research Fellow
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Project team

Dr Michael Curtis

Dr Michael Curtis

Postdoctoral Research Officer
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Associate Professor Jessica Howell

Associate Professor Jessica Howell

Co-head, Hepatitis B and Liver Cancer; Senior Research Fellow
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