The Depo Provera and Beyond study is a collaboration between multiple research institutes in the United States, South Africa and Australia, and clinical sites in South Africa, the Dominican Republic and Brazil.
The aims of this study are to investigate the effects of different long-acting contraceptives on the female genital tract including:
Another aim is to investigate interactions between contraceptives and the microbiome and inflammation that impact HIV acquisition risk.
This study includes clinical specimens and metadata that were collected in three randomised control trials:
2018–ongoing.
The ECHO clinical trial aimed to evaluate HIV incidence among women randomised to receive 3-monthly intramuscular doses of 150 mg of depot medroxyprogesterone acetate (DMPA), the copper intrauterine device or the levonorgestrel implant in South Africa, Kenya, Zambia and Swaziland.
The Depo Provera and Beyond sub-study is analysing samples collected from 168 South African participants at baseline, and month 1 and month 3 following contraceptive initiation. We additionally aim to analyse samples collected at baseline from 177 women who subsequently acquired HIV and 708 controls who remained HIV-uninfected during the trial.
Sayana Press Extension is a randomised trial to evaluate the contraceptive efficacy of Sayana Press (104 mg DMPA) injected every 4 months among women in the Dominican Republic, Chile and Brazil. Our sub-study is analysing samples collected from 23 participants in Brazil.
Lower Dose DMPA PK/PD Study aimed to evaluate suppression of ovulation of MPA after a single subcutaneous injection of DMPA-SQ 105 mg, 104 mg, 75 mg or 45 mg in the Dominican Republic, Chile and Brazil. Our sub-study is analysing samples collected from 40 participants in Brazil and the Dominican Republic.
American Journal of Reproductive Immunology
Lindi Masson
PLoS ONE
Jennifer Deese
National Institutes of Health (NIH)
Gates Foundation
US Agency for International Development and the President’s Emergency Plan for AIDS Relief
Swedish International Development Cooperation Agency
South African Medical Research Council
UN Population Fund
FHI 360
FHI 360
University of Cape Town
Virginia Commonwealth University
Oregon Health and Science University
Match Research Unit
Setshaba Research Centre
Wits Reproductive Health and HIV Institute
Effective Care Research Unit
Qhakaza Mbokodo Research Clinic
Profamilia
University of Campinas