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Malaria and other mosquito-borne diseases

Malaria and other mosquito-borne diseases

Mosquitos are the most lethal animal species to humans. Annually, diseases transmitted by mosquitoes kill more than one million people and infect up to 700 million. These diseases include malaria, dengue, Zika and Japanese encephalitis. Malaria causes over half of these deaths. Now, climate change is driving mosquitos into areas previously unaffected. In Europe, over the past decade, locally transmitted dengue outbreaks have increased. Burnet collaborates with teams worldwide to reduce the burden of mosquito-borne diseases and protect people at risk.

Malaria challenges

Malaria is the deadliest mosquito-borne disease. In 2023, there were an estimated 263 million malaria cases and 597,000 deaths in 83 countries. That amounts to approximately 68 deaths per hour. Ninety-five per cent of malaria-related deaths were in Africa. Seventy-six of these deaths were children under 5.

Every 70 seconds, a child under 5 years old dies because of malaria.

Malaria is caused when female Anopheles mosquitoes spread the Plasmodium parasite between humans.

The most significant Plasmodium species are:

P. falciparum, which causes the most deaths and is most common in Africa
P. vivax, which kills fewer people but can recur after lying dormant in the liver; harder to detect, it’s the most common species in the Pacific and South-East Asia.

After decades of public health effort, malaria was officially eliminated from Australia in 1981. However, reintroduction remains a risk.

Malaria is endemic in approximately 85 countries, including the Americas, Africa, Southeast Asia, Western Pacific and the Eastern Mediterranean region.

Malaria challenges include:

mosquitos becoming resistant to insecticides
parasites becoming resistant to anti-malarial drugs
warmer temperatures expanding mosquito habitats, spreading malaria to non-tropical regions
malaria-control programs losing funds due to lack of political will to continue them
health systems in low-resource areas providing limited care to vulnerable populations
limited effectiveness of current vaccines, lack of a vaccine for P. vivax
lack of an endorsed malaria vaccine for the Asia-Pacific region
rapid diagnostic tests becoming ineffective.

There's also a lack of sensitive tools for:

detecting and tracking the diversity of Plasmodium and Anopheles species
diagnosing low density or asymptomatic infections
detecting dormant liver-stage infections by Plasmodium.

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Other mosquito-borne diseases

We research other diseases carried by mosquitoes, including:

dengue: the most widespread mosquito-borne viral disease, increasingly common in the Pacific and parts of northern Australia
Zika virus and Japanese encephalitis: emerging threats with pandemic potential; Japanese Encephalitis might be endemic in Australia
Ross River virus and Barmah Forest virus: already endemic in Australia
chikungunya: it can cause similar symptoms to Zika and dengue; a compatible mosquito carrier already exists in Australia.

Climate change and mosquito-borne diseases

Climate change enables mosquitoes and the diseases they carry to spread into new regions. If health systems in such regions have limited resources, mosquito-borne diseases could become established there.

Our expertise

We combine laboratory discovery with public health implementation and expertise in international development.

We also work in close partnership with communities and health systems across Africa, South-East Asia and the Pacific.

Global objectives

Our work aligns with the World Health Organization’s Global Technical Strategy for Malaria 2016–2030, including:

a reduction of malaria case incidence and mortality rates by at least 90%
malaria eliminated in at least 35 countries
preventing re-establishment in malaria-free countries
the transformation of malaria surveillance into a core intervention
fostering innovation and expanding access to tools and technologies.

Diagnostics and surveillance

We develop and evaluate new diagnostic technologies to support earlier, more accurate detection of malaria, dengue, Zika and Japanese encephalitis. This includes tools for improved case management, genomic surveillance and resistance monitoring. For example, we’re investigating the integration of more sensitive malaria detection techniques into national surveillance systems.

Immunity and vaccines

We focus on understanding immune responses to Plasmodium falciparum and P. vivax to inform effective vaccine design.

Our laboratory research advances the development and evaluation of leading malaria vaccine candidates. For example, we’re researching immune responses generated by malaria vaccination in young children across Africa.

Drug discovery and resistance

We are developing new antimalarial drugs and tracking and preventing the spread of drug resistance, especially in the Asia-Pacific region.

We aim to accelerate deployment of new treatments. For example, we are researching new antimalarial drugs to overcome Plasmodium drug resistance.

Epidemiology and public health

Burnet conducts implementation research to improve healthcare services and malaria prevention.

We support modelling and evaluation of interventions for malaria across endemic regions. For example, in the Indo-Pacific region, our ADVANCE project aims to improve access to new malaria diagnostic tools.

Mosquito control

To achieve malaria elimination goals, we research mosquito behaviour and integrated control strategies.

To control the spread of viruses such as dengue, Zika and chikungunya, we study and evaluate use of the Wolbachia bacterium.

Our achievements

Burnet is at the forefront of research into mosquito-borne diseases. Our work influences global health policies, clinical guidelines and vaccine development.

Surveillance systems

In Papua New Guinea and the Greater Mekong region, we demonstrated how community-led molecular and serological surveillance can be integrated into national systems.

Digital innovation

In the Greater Mekong region and Papua New Guinea, we developed mobile app-based advanced malaria surveillance tools to improve case detection, surveillance and use of data for informed decision-making.

Vaccine design

We study targets from malaria parasites around the world. By knowing how much they differ, we can create a ‘guide’ to develop vaccines that work in multiple regions and against different strains.

We also delivered critical insights into the performance of the RTS,S malaria vaccine among young children in a malaria-endemic area.

Vaccine development

We identified protective antibody targets and predicted antigen combinations for highly effective vaccines. This work directly informed international vaccine development.

Drug resistance

In Papua New Guinea, we discovered a local emergence of artemisinin resistance mutations. This led to the World Health Organization (WHO) changing its definition of artemisinin resistance, increasing the accuracy of resistance surveillance.

Vector control

Burnet led the first trial demonstrating how personal mosquito repellent can prevent malaria. The WHO used this evidence to inform their regional policy. Together with partners in PNG, we are evaluating new vector control tools to target outdoor transmission.

Maternal and newborn health

We provided the first evidence that artemisinin drugs are safe to use in early pregnancy. As a result, the WHO revised its treatment guidelines. Our research linked malaria to 200,000 global stillbirths per year and showed how preventive treatment reduces the risk. Informed by our work, the WHO updated its policy in Asia.

Partnering to eliminate malaria in our region

Burnet, WEHI and the Australian Government have teamed up to work on malaria elimination with countries across the Pacific and South-East Asia.

Partnering to eliminate malaria in our region.

Featured publications

13 Apr 2023

Sulfonylpiperazine compounds prevent Plasmodium falciparum invasion of red blood cells through interference with actin-1/profilin dynamics

PLoS Biology

Zahra Razook, Madeline G. Dans, Somya Mehra, Molly Parkyn Schneider, Thorey K. Jonsdottir, Mikha Gabriela, Alyssa E. Barry, Brendan S. Crabb, Paul R. Gilson, Madeline G. Dans

18 Jun 2024

Aryl amino acetamides prevent Plasmodium falciparum ring development via targeting the lipid-transfer protein PfSTART1

Nature Communications

Zahra Razook, Madeline G. Dans, Coralie Boulet, Somya Mehra, Dawson B. Ling, Thorey K. Jonsdottir, Coralie Boulet, Madeline G. Dans, Somya Mehra, Zahra Razook