We identify and develop effective antimicrobial strategies for the prevention and control of pathogens including HIV.
We define the role of the genital microbiota and their metabolites in sexual and reproductive health outcomes. We discover and develop novel antivirals, and we identify and characterise mammalian retroviruses and antiviral proteins.
Our main objectives are to:
Our work has discovered vaginal microbiota metabolites that:
Our other discoveries include:
We've also demonstrated:
We’ve discovered Hervey pteropid gammaretrovirus, the first replication competent retrovirus circulating in Australian fruit bats, suggesting that bats can deal with multiple viral threats.
We investigate how a factor produced by optimal microbiota augments the cervicovaginal mucosal barrier to prevent HIV acquisition.
Drug resistance, toxicity and intolerance could exhaust antiretroviral drug options for HIV treatment and prevention, with few new drug classes in the pipeline.
Research Square (Research Square)
Catherine L Latham, Muriel Aldunate, David Tyssen, Adam Johnson, Joshua A. Hayward, Rob J. Center, Paul A. Ramsland, Anna C. Hearps, Gilda Tachedjian, Muriel Aldunate
Virus Evolution
Shuoshuo Tian, Joshua A. Hayward, Gilda Tachedjian, Joshua A. Hayward, Shuoshuo Tian, Gilda Tachedjian
Microbiome
Joshua A. Hayward, David Jose Delgado-Diaz, Brianna Jesaveluk, David Tyssen, Anna C. Hearps, Brianna Jesaveluk, David Jose Delgado-Diaz, Joshua A. Hayward, David Tyssen, Anna C. Hearps
Molecules
Adam Johnson, Catherine F. Latham, George W. Mbogo, Paula Ellenberg, David Tyssen, Gilda Tachedjian
Frontiers in Reproductive Health
David Tyssen, Anna C. Hearps, Lindi Masson, Gilda Tachedjian, AC Hearps
Proceedings of the National Academy of Sciences
Brianna Jesaveluk, Joshua A. Hayward, Adam Johnson, Christine Langer, Adam Werner, Dimitri Kontos, Pantelis Poumbourios, Heidi E. Drummer, Gilda Tachedjian, Adam Werner
Frontiers in Cellular and Infection Microbiology
Joshua A. Hayward, David Jose Delgado-Diaz, David Tyssen, Raffi Gugasyan, Anna C. Hearps, Gilda Tachedjian, David Jose Delgado-Diaz, David Tyssen, Joshua A. Hayward, Raffi Gugasyan
mSphere
Joshua A. Hayward, David Tyssen, Paul A. Agius, Muriel Aldunate, Gilda Tachedjian, David Tyssen, Joshua A. Hayward, Paul A. Agius, Muriel Aldunate, Gilda Tachedjian
Mucosal Immunology
Raffi Gugasyan, Anna C. Hearps, David Tyssen, Daniela Srbinovski, David Jose Delgado-Diaz, Muriel Aldunate, Gilda Tachedjian, Anna C. Hearps, David Tyssen, Daniela Srbinovski