Working groups
Tim is a PhD student at the Burnet Institute and Monash University. His supervisors are Professor James Beeson, Dr Linda Reiling, and Dr Lee Yeoh. The Beeson group focuses on defining the determinants of malaria immunity to develop novel malaria vaccines. Specifically, Tim’s research aims to improve the modest efficacy imparted by the leading pre-erythrocytic stage vaccine, RTS,S, which is based on the circumsporozoite protein. He is testing whether incorporating epitopes from this protein that are not present in RTS,S would better protective antibody responses in animal models.
In addition, Tim is investigating if MSP2, an abundant blood-stage protein, would be a suitable vaccine candidate. Using peptide screening arrays, immunoassays, and sera from exposed populations, he is identifying regions and epitopes of MSP2 that are associated with functional antibodies. Tim will then assess the protective potential of these regions in vaccine constructs. As a part of his research goals, Tim is also exploring if synergistic protection can be achieved when different malaria antigens are combined into a single vaccine.
Tim obtained an Honours degree from the University of Auckland in 2018, where he worked on Group A Streptococcus. Before starting his PhD, Tim also worked in the nutraceutical industry.
Trends in Parasitology
Timothy K.C. Ho, Alessia Hysa, K. E. Stoll Pekin, Timothy K.C. Ho, Alessia Hysa, K. E. Stoll Pekin
Trends in Parasitology
Timothy K.C. Ho, Alessia Hysa, K. E. Stoll Pekin, Timothy K.C. Ho, Alessia Hysa, K. E. Stoll Pekin
Clinical Infectious Diseases
Timothy K.C. Ho
The project identifies and prioritises candidate antigens for vaccine development.
Vaccination is a highly effective strategy to protect populations against infectious diseases. Highly protective and long-lasting vaccines are needed to reduce the global burden of malaria and enable elimination.
We're developing novel solutions and high-quality evidence to inform policies and practices that address the major barriers in malaria elimination.